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Clinical Infectious Diseases 46   
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doi:10.1086/529197

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Thema: 11/ibapublikationen
Institut für Biomedizinische Alternsforschung


IBA Publikation









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Clinical Infectious Diseases 46   
Open access


Birgit Weinberger, Dietmar Herndler-Brandstetter, Angelika Schwanninger, Daniela Weiskopf, Beatrix Grubeck-Loebenstein
PDF Icon  Biology of Immune Responses to Vaccines in the Elderly ()

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University of Chicago Press


doi:10.1086/529197
Abstract:
With increasing age the human immune system undergoes characteristic changestermed immunosenescence, which lead to increased incidence and severity of infectious diseases and to insufficient protection following vaccination. Functional defects and altered frequencies of innate and adaptive immune cells impair local responses at the site of vaccine injection, hamper the generation of primary responses to neo-antigens, prevent the effective induction of memory lymphocytes and decrease the effect of booster vaccination. As a result, antibody responses of elderly vaccinees are weaker and decline faster, and long-term protective effects of vaccination cannotbe taken for granted in the elderly. Improved vaccination strategies, new adjuvants and new vaccines that specifically target the aged immune system will help to overcome the limitations of immunosenescence and ensure a better protection of the vulnerable elderly population. Clinical Infectious Diseases (ISSN: 1058-4838), Copyright by University of Chicago Press

Keywords:  Vaccines
Volume:  46 
Published Online:  2008/08/06 12:37:05
Object Identifier:  0xc1aa5576 0x001b1e1d
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epub.oeaw – Institutionelles Repositorium der Österreichischen Akademie der Wissenschaften
epub.oeaw – Institutional Repository of the Austrian Academy of Sciences
A-1011 Wien, Dr. Ignaz Seipel-Platz 2
Tel. +43-1-515 81/DW 3420, Fax +43-1-515 81/DW 3400
http://epub.oeaw.ac.at, e-mail: epub@oeaw.ac.at