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Biotechnology Journal 2008;3-6   
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doi:10.1002/biot.200700254


Thema: 11/ibapublikationen
Institut für Biomedizinische Alternsforschung


IBA Publikation









IBA Publikation





Biotechnology Journal 2008;3-6   
Open access


H. Unterluggauer, E Hütter, H.P. Viertler, P. Jansen-Dürr
Digital Object Icon  Insulin-like growth factor induced signals activate mitochondrial respiration ()
S.  813 - 816
Open access

John Wiley & Sons Ltd.


doi:10.1002/biot.200700254
Abstract:
From experiments with lower eukaryotes it is known that the metabolic rate and also the rate of aging are tightly controlled by the IGF / insulin signal transduction pathway. The mitochondrial theory of aging implies that an increased metabolic rate leads to increased mitochondrial activity; increased production of reactive oxygen species due to these alterations would speed up the aging process. To address the question if mitochondrial activity is influenced by insulin / IGF signalling, we have established an experimental system to determine the influence of IGF-I dependent signalling on mitochondrial function. We used DU145 prostate cancer cells, known for the intact IGF signal transduction pathway, to address the influence of IGF receptor activation on mitochondrial function by high-resolution respirometry. These experiments revealed that indeed mitochondrial function is regulated by IGF signalling, and up-regulation of respiration seems to require PI3K/AKT signalling, but is independent of IGF effects on cell cycle progression. Collectively these data establish a regulatory cross-talk between insulin / IGF signal transduction and mitochondrial function, two major pathways implicated in controlling the rate of aging.

Keywords:  mitochondria insulin/IGF pathways respiration
  2008/10/02 06:46:42
Object Identifier:  0xc1aa5576 0x001bcce1
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epub.oeaw – Institutionelles Repositorium der Österreichischen Akademie der Wissenschaften
epub.oeaw – Institutional Repository of the Austrian Academy of Sciences
A-1011 Wien, Dr. Ignaz Seipel-Platz 2
Tel. +43-1-515 81/DW 3420, Fax +43-1-515 81/DW 3400
http://epub.oeaw.ac.at, e-mail: epub@oeaw.ac.at