Institut für Biomedizinische Alternsforschung


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Internation Journal of Probiotics and Prebiotics 2008;3-3   
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Thema: 11/ibapublikationen
Institut für Biomedizinische Alternsforschung


IBA Publikation









IBA Publikation





Internation Journal of Probiotics and Prebiotics 2008;3-3   
Open access


Dietmar Herndler-Brandstetter, Beatrix Grubeck-Loebenstein
Digital Object Icon  Changes within the immune system from Birth to Old Age ()
S.  119 - 122
Open access

International Journal of Probiotics and Prebiotics

Abstract:
A wide range of age-related alterations in immune system function have been described which contribute to the high prevalence, the more severe disease course and the poorer prognosis of certain infectious diseases in the elderly population and the low efficacy of vaccinations. Moreover, the development and progression of other agerelated diseases, such as certain cancers, atherosclerosis, dementia, osteoporosis and rheumatoid arthritis have been associated with altered immune function in old age. The most prominent event contributing to immunosenescence is the involution of the thymus which leads to a dramatic loss of T cell function. It is therefore of great importance to fully assess age-related changes within the immune system and to develop strategies aiming at restoring immune system function in elderly persons.

Published Online:  2008/12/01 12:20:56
Object Identifier:  0xc1aa5576 0x001c9485
Rights:All rights reserved.For questions regarding copyright and copies please contact us by email.


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epub.oeaw – Institutionelles Repositorium der Österreichischen Akademie der Wissenschaften
epub.oeaw – Institutional Repository of the Austrian Academy of Sciences
A-1011 Wien, Dr. Ignaz Seipel-Platz 2
Tel. +43-1-515 81/DW 3420, Fax +43-1-515 81/DW 3400
http://epub.oeaw.ac.at, e-mail: epub@oeaw.ac.at