IBA Publikation
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DATUM, UNTERSCHRIFT / DATE, SIGNATURE
BANK AUSTRIA CREDITANSTALT, WIEN (IBAN AT04 1100 0006 2280 0100, BIC BKAUATWW), DEUTSCHE BANK MÜNCHEN (IBAN DE16 7007 0024 0238 8270 00, BIC DEUTDEDBMUC)
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IBA Publikation IBA Publikation
Transfus Med Hemother 2008;35
Günter Lepperdinger,
Regina Brunauer,
Robert Gassner,
Angelika Jamnig,
Frank Kloss,
Gerhard Laschober
S. 299 - 305 Karger doi:10.1159/000142373
Abstract: In contrast to stem cells of embryonic origin, autologous tissue-specific stem cells are easier to introduce into the clinical practice. In this context however, molecular and cellular changes, which alter tissue-specific stem cell properties with age, are of particular interest, since elderly patients represent the main target group for cellbased therapies. The clinical use of mesenchymal stem cells is an emerging field, especially because this stem cell type appears to be amenable for the treatment of a large number of diseases, such as non-healing bone defects and fractures, inflammatory relieve during arthritis, and the repair of suspensory ligament tears. More than that, mesenchymal stem cells provoke effective immune suppression in the context of graft-versus-host disease. Here, we present a comprehensive overview of the recent findings with special attention to age-related changes of mesenchymal stem cells properties and the consequential impact involved on tissue regeneration and repair, together with the current perception concerning their therapeutic application potential as well as challenges associated with their clinical use. Keywords: mesenchymal stem cells, aging Published Online: 2009/02/03 14:49:54 Object Identifier: 0xc1aa5576 0x001d4fd7 Rights: .
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epub.oeaw – Institutionelles Repositorium der Österreichischen Akademie der Wissenschaften epub.oeaw – Institutional Repository of the Austrian Academy of Sciences
A-1011 Wien, Dr. Ignaz Seipel-Platz 2
Tel. +43-1-515 81/DW 3420, Fax +43-1-515 81/DW 3400 http://epub.oeaw.ac.at, e-mail: epub@oeaw.ac.at |