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Biomaterials 2008;29  
Open access


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doi:10.1016/j.biomaterials.2008.01.036


Thema: 11/ibapublikationen
Institut für Biomedizinische Alternsforschung


IBA Publikation









IBA Publikation





Biomaterials 2008;29  
Open access


F.R. Kloss, R. Gassner, J. Preiner, A. Ebner, K. Larsson, O. Hächl, T. Tuli, M. Rasse, D. Moser, K. Laimer, E.A. Nickel, G. Laschober, R. Brunauer, G. Klima, P. Hinterdorfer, D. Steinmüller-Nethl, G. Lepperdinger
S.  2433 - 2442
Open access

Elsevier


doi:10.1016/j.biomaterials.2008.01.036
Abstract:
Medical implants are increasingly often inserted into bone of frail patients, who are advanced in years. Due to age, severe trauma or pathology-related bone changes, osseous healing at the implant site is frequently limited. We were able to demonstrate that coating of endosseous implants with nanocrystalline diamond (NCD) allows stable functionalization by means of physisorption with BMP-2. Strong physisorption was shown to be directly related to the unique properties of NCD, and BMP-2 in its active form interacted strongest when NCD was oxygen-terminated. The binding of the protein was monitored under physiological conditions by single molecule force spectroscopy, and the respective adsorption energies were further substantiated by force-field-calculations. Implant surfaces refined in such a manner yielded enhanced osseointegration in vivo, when inserted into sheep calvaria. Our results further suggest that this technical advancement can be readily applied in clinical therapies with regard to bone healing, since primary human mesenchymal stromal cells strongly activated the expression of osteogenic markers when being cultivated on NCD physisorbed with physiological amounts of BMP-2.

Keywords:  nano-crystalline diamond (NCD), physisorption, bone morphogenetic protein-2 (BMP-2), bone regeneration, mesenchymal stem cells
  2009/02/04 13:56:20
Object Identifier:  0xc1aa5576 0x001e1ceb
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epub.oeaw – Institutionelles Repositorium der Österreichischen Akademie der Wissenschaften
epub.oeaw – Institutional Repository of the Austrian Academy of Sciences
A-1011 Wien, Dr. Ignaz Seipel-Platz 2
Tel. +43-1-515 81/DW 3420, Fax +43-1-515 81/DW 3400
http://epub.oeaw.ac.at, e-mail: epub@oeaw.ac.at