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Trends in Immunology 2009;30-7   
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doi:10.1016/j.it.2009.05.002


Thema: 11/ibapublikationen
Institut für Biomedizinische Alternsforschung


IBA Publikation









IBA Publikation





Trends in Immunology 2009;30-7   
Open access


Wilbur H. Chen, Bernard F. Kozlovsky, Rita B. Effros, Beatrix Grubeck-Loebenstein, Robert Edelman, Marcelo B. Sztein
PDF Icon  Vaccination in the elderly: an immunological perspective ()
S.  351 - 359
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doi:10.1016/j.it.2009.05.002
Abstract:
Successful vaccination of the elderly against important infectious pathogens that cause high morbidity and mortality represents a growing public health priority. Building on the theme of aging and immunosenescence, we review mechanisms of human immunosenescence and the immune response to currently licensed vaccines. We discuss the difficulties in identifying the risk factors that, in addition to aging, cause immunosenescence and address the relative paucity of vaccine studies in the elderly. We conclude that vaccine responses are blunted in the elderly compared with that of healthy young adults. However, it is also clear that our understanding of the mechanisms underlying immunosenescence is limited and much remains to be learned to improve the effectiveness of next generation vaccines.

  2009/08/03 09:55:35
Document Date:  2009/08/03 09:49:00
Object Identifier:  0xc1aa5576 0x002240b6
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epub.oeaw – Institutionelles Repositorium der Österreichischen Akademie der Wissenschaften
epub.oeaw – Institutional Repository of the Austrian Academy of Sciences
A-1011 Wien, Dr. Ignaz Seipel-Platz 2
Tel. +43-1-515 81/DW 3420, Fax +43-1-515 81/DW 3400
http://epub.oeaw.ac.at, e-mail: epub@oeaw.ac.at