Institut für Biomedizinische Alternsforschung


IBA Publikation









IBA Publikation





Biogerontology 10/2   
Open access


epub.oeaw – Institutionelles Repositorium der Österreichischen Akademie der Wissenschaften
epub.oeaw – Institutional Repository of the Austrian Academy of Sciences
A-1011 Wien, Dr. Ignaz Seipel-Platz 2
Tel. +43-1-515 81/DW 3420, Fax +43-1-515 81/DW 3400
http://epub.oeaw.ac.at, e-mail: epub@oeaw.ac.at

Bestellung/Order








IBA Publikation
IBA Publikation







Send or fax to your local bookseller or to:

Verlag der Österreichischen Akademie der Wissenschaften
Austrian Academy of Sciences Press
A-1011 Wien, Dr. Ignaz Seipel-Platz 2,
Tel. +43-1-515 81/DW 3420, Fax +43-1-515 81/DW 3400
https://verlag.oeaw.ac.at, e-mail: bestellung.verlag@oeaw.ac.at
UID-Nr.: ATU 16251605, FN 71839x Handelsgericht Wien, DVR: 0096385

Bitte senden Sie mir
Please send me
 
Exemplar(e) der genannten Publikation
copy(ies) of the publication overleaf


NAME


ADRESSE / ADDRESS


ORT / CITY


LAND / COUNTRY


ZAHLUNGSMETHODE / METHOD OF PAYMENT
    Visa     Euro / Master     American Express


NUMMER

Ablaufdatum / Expiry date:  

    I will send a cheque           Vorausrechnung / Send me a proforma invoice
 
DATUM, UNTERSCHRIFT / DATE, SIGNATURE

BANK AUSTRIA CREDITANSTALT, WIEN (IBAN AT04 1100 0006 2280 0100, BIC BKAUATWW), DEUTSCHE BANK MÜNCHEN (IBAN DE16 7007 0024 0238 8270 00, BIC DEUTDEDBMUC)
X
BibTEX-Export:

X
EndNote/Zotero-Export:

X
RIS-Export:

X 
Researchgate-Export (COinS)

Permanent QR-Code

doi:10.1007/s10522-008-9167-1


Thema: 11/ibapublikationen
Institut für Biomedizinische Alternsforschung


IBA Publikation









IBA Publikation





Biogerontology 10/2   
Open access


Lutfan Lazuardi Lazuardi, Dietmar Herndler-Brandstetter, Stefan Brunner, Beatrix Grubeck- Loebenstein
S.  191 - 202
Open access

The original publication is available at www.springerlink.com


doi:10.1007/s10522-008-9167-1
Abstract:
We isolated highly purified CD8+CD28+ and CD8+CD28– T cells populations from healthy young and elderly persons for gene expression profiling using Affymetrix oligonucleotide microarrays. We demonstrate that the gene expression profile of CD8+CD28– T cells is very similar in young and elderly persons. In contrast, CD8+CD28+ in elderly differ from CD8+CD28+ in young persons. Hierarchical clustering revealed that CD8+CD28+ in elderly are located between CD8+CD28+ in young and CD8+CD28– (young and old) T cells regarding their differentiation state. Our study demonstrates a dichotomy of gene expression levels between CD8+CD28+ T cells in young and elderly persons but a similarity between CD8+CD28– T cells in young and elderly persons. As CD8+CD28+ T cells from elderly and young persons are distinct due to a different composition of the population, these results suggest that the gene expression profile does not depend on chronological age but depends on the differentiation state of the individual cell types. The original publication is available at www.springerlink.com

Keywords:  Aging, humans, CD8+ T cell, gene expression
  2009/08/04 10:03:31
Object Identifier:  0xc1aa5576 0x002240ba
.



Vergessen Sie nicht das Login am Server, wenn Sie auf Kapitel zugreifen wollen, die nicht allgemein zugänglich sind.
Links zu diesen Dokumenten werden erst nach dem Login sichtbar.
Do not forget to Login on the server if you want to access chapters that are not freely accessible.
Links to these documents will only be visible after logon.

epub.oeaw – Institutionelles Repositorium der Österreichischen Akademie der Wissenschaften
epub.oeaw – Institutional Repository of the Austrian Academy of Sciences
A-1011 Wien, Dr. Ignaz Seipel-Platz 2
Tel. +43-1-515 81/DW 3420, Fax +43-1-515 81/DW 3400
http://epub.oeaw.ac.at, e-mail: epub@oeaw.ac.at