IBA Publikation
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epub.oeaw – Institutionelles Repositorium der Österreichischen Akademie der Wissenschaften epub.oeaw – Institutional Repository of the Austrian Academy of Sciences
A-1011 Wien, Dr. Ignaz Seipel-Platz 2
epub.oeaw – Institutionelles Repositorium der Österreichischen Akademie der WissenschaftenTel. +43-1-515 81/DW 3420, Fax +43-1-515 81/DW 3400 http://epub.oeaw.ac.at, e-mail: epub@oeaw.ac.at epub.oeaw – Institutional Repository of the Austrian Academy of Sciences
A-1011 Wien, Dr. Ignaz Seipel-Platz 2
Tel. +43-1-515 81/DW 3420, Fax +43-1-515 81/DW 3400 http://epub.oeaw.ac.at, e-mail: epub@oeaw.ac.at |
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DATUM, UNTERSCHRIFT / DATE, SIGNATURE
BANK AUSTRIA CREDITANSTALT, WIEN (IBAN AT04 1100 0006 2280 0100, BIC BKAUATWW), DEUTSCHE BANK MÜNCHEN (IBAN DE16 7007 0024 0238 8270 00, BIC DEUTDEDBMUC)
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IBA Publikation IBA Publikation
Christoph Zenzmaier,
Josef Marksteiner,
Andreas Kiefer,
Peter Berger,
Christian Humpel
S. 653 - 661 Wiley doi:10.1111/j.1471-4159.2009.06158.x
Abstract: Biomarkers in cerebrospinal fluid (CSF) can offer improved diagnostic accuracy for Alzheimer’s disease (AD). The present study investigated whether the glycoprotein and putative tumor suppressor Dkk-3 is secreted into CSF and evaluated its applicability as a diagnostic marker for AD. Using our highly specific IEMA Dkk-3 levels were measured in plasma and/or CSF of patients suffering from depression, mild cognitive impairment (MCI) or AD and compared with healthy subjects. Dkk-3 identity was verified by Western Blot and MALDI-TOF MS/MS. High concentrations of Dkk-3 were detected in CSF compared with plasma (28.2±1.3 vs. 1.22±0.04 nmol/l, respectively). Consistently Dkk-3 expression was demonstrated in neurons of the cortex and epithelial cells of the choroid plexus, the major source of CSF. Significantly increased Dkk-3 levels in plasma and CSF were observed for AD patients compared with healthy subjects but not patients suffering from MCI or depression. In summary our data indicate that elevated Dkk-3 levels are specifically associated with AD and might serve as a potential non-invasive AD biomarker in plasma. Keywords: Alzheimer’s disease, β-amyloid(1-42), cerebrospinal fluid, Dickkopf-3, tau, p-tau-181 Published Online: 2009/09/22 12:35:10 Object Identifier: 0xc1aa5576 0x002298dc Rights: .
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epub.oeaw – Institutionelles Repositorium der Österreichischen Akademie der Wissenschaften epub.oeaw – Institutional Repository of the Austrian Academy of Sciences
A-1011 Wien, Dr. Ignaz Seipel-Platz 2
epub.oeaw – Institutionelles Repositorium der Österreichischen Akademie der WissenschaftenTel. +43-1-515 81/DW 3420, Fax +43-1-515 81/DW 3400 http://epub.oeaw.ac.at, e-mail: epub@oeaw.ac.at epub.oeaw – Institutional Repository of the Austrian Academy of Sciences
A-1011 Wien, Dr. Ignaz Seipel-Platz 2
Tel. +43-1-515 81/DW 3420, Fax +43-1-515 81/DW 3400 http://epub.oeaw.ac.at, e-mail: epub@oeaw.ac.at |