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Transplant International 2009;22   
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doi:10.1111/j.1432-2277.2009.00927.x

  Online Edition 

Thema: 11/ibapublikationen
Institut für Biomedizinische Alternsforschung


IBA Publikation









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Transplant International 2009;22   
Open access


D. Weiskopf, B. Weinberger, B. Grubeck-Loebenstein
Digital Object Icon  The aging of the immune system ()
S.  1041 - 1050
Open access

Wiley-Blackwell


doi:10.1111/j.1432-2277.2009.00927.x
Abstract:
An age-related decline in immune functions, referred to as immunosenescence, is partially responsible for the increased prevalence and severity of infectious diseases, and the low efficacy of vaccination in elderly persons. Immunosenescence is characterized by a decrease in cell-mediated immune function as well as by reduced humoral immune responses. Age-dependent defects in T- and B-cell function coexist with age-related changes within the innate immune system. In this review, we discuss the mechanisms and consequences of age-associated immune alterations as well as their implications for health in old age.

Published Online:  2009/11/06 09:54:48
Object Identifier:  0xc1aa5576 0x0022a4ec
Rights:All rights reserved.For questions regarding copyright and copies please contact us by email.


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epub.oeaw – Institutionelles Repositorium der Österreichischen Akademie der Wissenschaften
epub.oeaw – Institutional Repository of the Austrian Academy of Sciences
A-1011 Wien, Dr. Ignaz Seipel-Platz 2
Tel. +43-1-515 81/DW 3420, Fax +43-1-515 81/DW 3400
http://epub.oeaw.ac.at, e-mail: epub@oeaw.ac.at