Institut für Biomedizinische Alternsforschung


IBA Publikation









IBA Publikation





Endocrinology 2010; 151(8)   
Open access


epub.oeaw – Institutionelles Repositorium der Österreichischen Akademie der Wissenschaften
epub.oeaw – Institutional Repository of the Austrian Academy of Sciences
A-1011 Wien, Dr. Ignaz Seipel-Platz 2
Tel. +43-1-515 81/DW 3420, Fax +43-1-515 81/DW 3400
http://epub.oeaw.ac.at, e-mail: epub@oeaw.ac.at

Bestellung/Order








IBA Publikation
IBA Publikation







Send or fax to your local bookseller or to:

Verlag der Österreichischen Akademie der Wissenschaften
Austrian Academy of Sciences Press
A-1011 Wien, Dr. Ignaz Seipel-Platz 2,
Tel. +43-1-515 81/DW 3420, Fax +43-1-515 81/DW 3400
https://verlag.oeaw.ac.at, e-mail: bestellung.verlag@oeaw.ac.at
UID-Nr.: ATU 16251605, FN 71839x Handelsgericht Wien, DVR: 0096385

Bitte senden Sie mir
Please send me
 
Exemplar(e) der genannten Publikation
copy(ies) of the publication overleaf


NAME


ADRESSE / ADDRESS


ORT / CITY


LAND / COUNTRY


ZAHLUNGSMETHODE / METHOD OF PAYMENT
    Visa     Euro / Master     American Express


NUMMER

Ablaufdatum / Expiry date:  

    I will send a cheque           Vorausrechnung / Send me a proforma invoice
 
DATUM, UNTERSCHRIFT / DATE, SIGNATURE

BANK AUSTRIA CREDITANSTALT, WIEN (IBAN AT04 1100 0006 2280 0100, BIC BKAUATWW), DEUTSCHE BANK MÜNCHEN (IBAN DE16 7007 0024 0238 8270 00, BIC DEUTDEDBMUC)
X
BibTEX-Export:

X
EndNote/Zotero-Export:

X
RIS-Export:

X 
Researchgate-Export (COinS)

Permanent QR-Code

doi:10.1210/en.2009-1411


Thema: 11/ibapublikationen
Institut für Biomedizinische Alternsforschung


IBA Publikation









IBA Publikation





Endocrinology 2010; 151(8)   
Open access


Christoph Zenzmaier, Natalie Sampson, Dominik Pernkopf, Eugen Plas, Gerold Untergasser, Peter Berger
S.  3975 - 3984
Open access

Extern


doi:10.1210/en.2009-1411
Abstract:
Benign prostatic hyperplasia (BPH) is characterized by tissue overgrowth and stromal reorganization primarily due to cellular proliferation and fibroblast-to-myofibroblast transdifferentiation. To evaluate the potential of PDE5 inhibitors like tadalafil for prevention and treatment of BPH we analyzed the role of the NO/cGMP/PDE5 pathway for cellular proliferation and transforming growth factor beta 1 (TGFβ1)- induced fibroblast-to-myofibroblast transdifferentiation in primary prostate stromal cells (PrSC). Inhibition by tadalafil of PDE5 which is mainly expressed in the stromal compartment of the prostate reduced proliferation of PrSCs and to a lesser extent of primary prostate basal epithelial cells. Attenuated proliferation due to elevated intracellular cGMP levels was confirmed by inhibition of the cGMP dependent protein kinase G by its inhibitor KT2358. Moreover, tadalafil strongly attenuated TGFβ1- induced fibroblast-to-myofibroblast transdifferentiation. The inhibitory effect on transdifferentiation was also observed after siRNA-mediated PDE5 knockdown. As confirmed by the MEK1 inhibitor PD98059 this effect was mediated via MEK1 signaling. We conclude that BPH patients might benefit from adjuvant therapies with PDE5 inhibitors that inhibit stromal enlargement due to cell proliferation as well as TGFβ1- induced transdifferentiation processes.

Keywords:  Benign-prostatic-hyperplasia Fibroblast-to-myofibroblast-transdifferentiation Lower-urinary-tract -symptoms PDE5 proliferation tadalafil
  2011/02/15 13:42:35
Object Identifier:  0xc1aa5576 0x00254e42
.



Vergessen Sie nicht das Login am Server, wenn Sie auf Kapitel zugreifen wollen, die nicht allgemein zugänglich sind.
Links zu diesen Dokumenten werden erst nach dem Login sichtbar.
Do not forget to Login on the server if you want to access chapters that are not freely accessible.
Links to these documents will only be visible after logon.

epub.oeaw – Institutionelles Repositorium der Österreichischen Akademie der Wissenschaften
epub.oeaw – Institutional Repository of the Austrian Academy of Sciences
A-1011 Wien, Dr. Ignaz Seipel-Platz 2
Tel. +43-1-515 81/DW 3420, Fax +43-1-515 81/DW 3400
http://epub.oeaw.ac.at, e-mail: epub@oeaw.ac.at