Institut für Biomedizinische Alternsforschung


IBA Publikation









IBA Publikation





Aging (Albany NY) 2010;2   
Open access


Verlag der Österreichischen Akademie der Wissenschaften
Austrian Academy of Sciences Press
A-1011 Wien, Dr. Ignaz Seipel-Platz 2
Tel. +43-1-515 81/DW 3420, Fax +43-1-515 81/DW 3400
https://verlag.oeaw.ac.at, e-mail: verlag@oeaw.ac.at

Bestellung/Order








IBA Publikation
IBA Publikation







Send or fax to your local bookseller or to:

Verlag der Österreichischen Akademie der Wissenschaften
Austrian Academy of Sciences Press
A-1011 Wien, Dr. Ignaz Seipel-Platz 2,
Tel. +43-1-515 81/DW 3420, Fax +43-1-515 81/DW 3400
https://verlag.oeaw.ac.at, e-mail: bestellung.verlag@oeaw.ac.at
UID-Nr.: ATU 16251605, FN 71839x Handelsgericht Wien, DVR: 0096385

Bitte senden Sie mir
Please send me
 
Exemplar(e) der genannten Publikation
copy(ies) of the publication overleaf


NAME


ADRESSE / ADDRESS


ORT / CITY


LAND / COUNTRY


ZAHLUNGSMETHODE / METHOD OF PAYMENT
    Visa     Euro / Master     American Express


NUMMER

Ablaufdatum / Expiry date:  

    I will send a cheque           Vorausrechnung / Send me a proforma invoice
 
DATUM, UNTERSCHRIFT / DATE, SIGNATURE

BANK AUSTRIA CREDITANSTALT, WIEN (IBAN AT04 1100 0006 2280 0100, BIC BKAUATWW), DEUTSCHE BANK MÜNCHEN (IBAN DE16 7007 0024 0238 8270 00, BIC DEUTDEDBMUC)
X
BibTEX-Export:

X
EndNote/Zotero-Export:

X
RIS-Export:

X 
Researchgate-Export (COinS)

Permanent QR-Code

Thema: 11/ibapublikationen
Institut für Biomedizinische Alternsforschung


IBA Publikation









IBA Publikation





Aging (Albany NY) 2010;2   
Open access


Wolfgang Wagner, Simonem Bork, Günther Lepperdinger, Sylvia Joussen, Nan Ma, Dirk Strunk, Carmen Koch
Digital Object Icon  How to track cellular aging of mesenchymal stromal cells? ()
S.  224 - 230
Open access
Abstract:
Mesenchymal stromal cells (MSC) are currently tested in a large number of clinical trials and raise high hope in regenerative medicine. These cells have to be expanded in vitro before transplantation and several studies demonstrated that long-term culture evokes continuous changes in MSC: proliferation rate decays, the cell size increases, differentiation potential is affected, chromosomal instabilities may arise and molecular changes are acquired. Long-term culture of cell preparations might also have therapeutic consequences, although this has hardly been addressed in ongoing trials so far. Reliable therapeutic regimens necessitate quality control of cellular products. This research perspective summarizes available methods to track cellular aging of MSC. We have demonstrated that gene expression changes and epigenetic modifications are continuously acquired during replicative senescence. Molecular analysis of a suitable panel of genes might provide a robust tool to assess efficiency and safety of long-term expansion.

Keywords:  mesenchymal-stem-cells replicative-senescence long-term-culture senescence-marker gene-expression
  2011/04/20 08:43:22
Document Date:  2010/08/04 08:39:00
Object Identifier:  0xc1aa5576 0x00277db8
.



Vergessen Sie nicht das Login am Server, wenn Sie auf Kapitel zugreifen wollen, die nicht allgemein zugänglich sind.
Links zu diesen Dokumenten werden erst nach dem Login sichtbar.
Do not forget to Login on the server if you want to access chapters that are not freely accessible.
Links to these documents will only be visible after logon.

Verlag der Österreichischen Akademie der Wissenschaften
Austrian Academy of Sciences Press
A-1011 Wien, Dr. Ignaz Seipel-Platz 2
Tel. +43-1-515 81/DW 3420, Fax +43-1-515 81/DW 3400
https://verlag.oeaw.ac.at, e-mail: verlag@oeaw.ac.at