IBA Publikation
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Verlag der Österreichischen Akademie der Wissenschaften Austrian Academy of Sciences Press
A-1011 Wien, Dr. Ignaz Seipel-Platz 2
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DATUM, UNTERSCHRIFT / DATE, SIGNATURE
BANK AUSTRIA CREDITANSTALT, WIEN (IBAN AT04 1100 0006 2280 0100, BIC BKAUATWW), DEUTSCHE BANK MÜNCHEN (IBAN DE16 7007 0024 0238 8270 00, BIC DEUTDEDBMUC)
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IBA Publikation IBA Publikation
Aging Cell 2010;9
Gerhard T. Laschober,
Doris Ruli,
Edith Hofer,
Christoph Muck,
Didac Carmona-Gutierrez,
Julia Ring,
Eveline Hutter,
Christoph Ruckenstuhl,
Lucia Micutkova,
Regina Brunauer,
Angelika Jamnig,
Daniela Trimmel,
Dietmar Herndler-Brandstetter,
Stefan Brunner,
Christoph Zenzmaier,
Natalie Sampson,
Michael Breitenbach,
Kai-Uwe Fröhlich,
Beatrix Grubeck-Loebenstein,
Peter Berger,
Matthias Wieser,
Regina Grillari-Voglauer,
Gerhard G. Thallinger,
Johannes Grillari,
Zlatko Trajanoski,
Frank Madeo,
Günter Lepperdinger,
Pidder Jansen-Dürr
S. 1084 - 1097 doi:10.1111/j.1474-9726.2010.00637.x
Abstract: To identify new genetic regulators of cellular aging and senescence, we performed genome-wide comparative RNA profiling with selected human cellular model systems, reflecting replicative senescence, stress-induced premature senescence, and distinct other forms of cellular aging. Gene expression profiles were measured, analyzed, and entered into a newly generated database referred to as the GiSAO database. Bioinformatic analysis revealed a set of new candidate genes, conserved across the majority of the cellular aging models, which were so far not associated with cellular aging, and highlighted several new pathways that potentially play a role in cellular aging. Several candidate genes obtained through this analysis have been confirmed by functional experiments, thereby validating the experimental approach. The effect of genetic deletion on chronological lifespan in yeast was assessed for 93 genes where (i) functional homologues were found in the yeast genome and (ii) the deletion strain was viable. We identified several genes whose deletion led to significant changes of chronological lifespan in yeast, featuring both lifespan shortening and lifespan extension. In conclusion, an unbiased screen across species uncovered several so far unrecognized molecular pathways for cellular aging that are conserved in evolution. Keywords: aging evolution replicative-lifespan replicative-senescence senescence yeast Published Online: 2011/04/19 15:13:24 Document Date: 2010/10/28 15:12:00 Object Identifier: 0xc1aa5576 0x00275269 Rights: .
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Verlag der Österreichischen Akademie der Wissenschaften Austrian Academy of Sciences Press
A-1011 Wien, Dr. Ignaz Seipel-Platz 2
Tel. +43-1-515 81/DW 3420, Fax +43-1-515 81/DW 3400 https://verlag.oeaw.ac.at, e-mail: verlag@oeaw.ac.at |