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IBA Publikation

Increase of Dkk-3 Blood Plasma Levels in the Elderly

    Christoph Zenzmaier, Lilian Sklepos, Peter Berger

IBA Publikation, pp. 867-870, 2008/10/01

doi: 10.1016/j.exger.2008.05.012


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doi:10.1016/j.exger.2008.05.012

Abstract

Gene expression of the secreted glycoprotein Dkk-3 is upregulated during cellular senescence in prostate basal epithelial cells and altered in age-related disorders of the human prostate. In order to quantify the influence of such age- and diseaserelated changes of Dkk-3 levels in body fluids, we established a highly specific and sensitive indirect IEMA. Results revealed a significant increase of Dkk-3 blood plasma levels in the elderly indicating a non negligible physiological role and its use as a marker for senescence not only in vitro but also in vivo.

Keywords: Dickkopf Blood Plasma IEMA Aging