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IBA Publikation

CD28‐ CD8+ T cells do not contain unique clonotypes and are therefore dispensable

    B. Weinberger, K. Welzl, D. Herndler-Brandstetter, W. Parson, B. Grubeck-Loebenstein

IBA Publikation, pp. 27-32, 2010/07/12

doi: 10.1016/j.imlet.2009.08.008


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doi:10.1016/j.imlet.2009.08.008

Abstract

Highly differentiated CD28‐ effector T cells which accumulate in a variety of diseases and also with increasing age contribute to inflammatory processes, limit immunological space and diversity, and are associated with immunological dysfunction and reduced responses tovaccination. Elimination of CD28‐ T cells has been suggested as a measure for immunological rejuvenation but may lead to the loss of important T cell specificities. Using T cells specific for the immunodominant CMV‐derived epitope NLVPMVATV as a model, we show that the same clonotypes are present in CD8+CD28+ naïve/early memory and CD8+CD28‐ effector T cells. Therefore, CD28‐ cells do not seem to contain clones which are not present in the residual population. The elimination of effector T cells would not lead to the loss of important specificities, as relevant clonotypes could be recruited and propagated from naïve or early memory T cell subsets in the case of exposure to pathogen.

Keywords: CMV‐specific T cell, elimination, immunosenescence, T cell receptor