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IBA Publikation

Gain and loss of T cell subsets in old age – Age-related reshaping of the T cell repertoire

    C. Arnold, J. Wolf, S. Brunner, D. Herndler-Brandstetter, B. Grubeck-Loebenstein

IBA Publikation, pp. , 2011/01/18

doi: 10.1007/s10875-010-9499-x


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doi:10.1007/s10875-010-9499-x

Abstract

The immune system is affected by the aging process and undergoes significant agerelatedchanges, termed immunosenescence. Different T cell subsets are affected bythis process. Alterations within the bone marrow and thymus lead to a shift in thecomposition of the T cell repertoire from naïve to antigen-experienced T cells, therebycompromising the diversity of the T cell pool. Additional infection with latent pathogenssuch as Cytomegalovirus aggravates this process. In this review we focus on the majorage-related changes that occur in the naïve and the antigen-experienced T cellpopulation. We discuss the mechanisms responsible for the generation andmaintenance of these subsets and how age-related changes can be delayed orprevented by clinical interventions.

Keywords: Immunosenescence T-cells aging human