![]() |
![]() |
IBA Publikation
|
![]() |
epub.oeaw – Institutionelles Repositorium der Österreichischen Akademie der Wissenschaften epub.oeaw – Institutional Repository of the Austrian Academy of Sciences
A-1011 Wien, Dr. Ignaz Seipel-Platz 2
Tel. +43-1-515 81/DW 3420, Fax +43-1-515 81/DW 3400 http://epub.oeaw.ac.at, e-mail: epub@oeaw.ac.at |
![]() |
|
DATUM, UNTERSCHRIFT / DATE, SIGNATURE
BANK AUSTRIA CREDITANSTALT, WIEN (IBAN AT04 1100 0006 2280 0100, BIC BKAUATWW), DEUTSCHE BANK MÜNCHEN (IBAN DE16 7007 0024 0238 8270 00, BIC DEUTDEDBMUC)
|
IBA Publikation, pp. , 2011/01/18
The immune system is affected by the aging process and undergoes significant agerelatedchanges, termed immunosenescence. Different T cell subsets are affected bythis process. Alterations within the bone marrow and thymus lead to a shift in thecomposition of the T cell repertoire from naïve to antigen-experienced T cells, therebycompromising the diversity of the T cell pool. Additional infection with latent pathogenssuch as Cytomegalovirus aggravates this process. In this review we focus on the majorage-related changes that occur in the naïve and the antigen-experienced T cellpopulation. We discuss the mechanisms responsible for the generation andmaintenance of these subsets and how age-related changes can be delayed orprevented by clinical interventions.
Keywords: Immunosenescence T-cells aging human