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IBA Publikation


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IBA Publikation
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IBA Publikation

Mucosal CD8 Memory T Cells are selected in the periphery by an MHC Class I Molecule

    Y. Huang, Y. Wang-Zhu, A. Larange, R. Arens, I. Bernardo, D. Olivares-Villagómez, D. Herndler-Brandstätter, N. Abraham, B. Grubeck-Loebenstein, S.P. Schoenberger, L. Van Kaer, M. Kronenberg, M.A. Teitell, H. Cheroutre

IBA Publikation, pp. 1-51, 2011/12/06

doi: 10.1038/ni.2106


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doi:10.1038/ni.2106

Abstract

The presence of immune memory at pathogen entry sites is a prerequisite for protection. Nevertheless, the mechanisms that warrant immunity at peripheral interfaces are not understood. Here we show that the non-classical MHC class I molecule, the thymus leukemia antigen (TL), induced on dendritic cells together with CD8aa on activated CD8αβ+T cells, mediates affinity-based selection of memory precursor cells. Furthermore, constitutive expression of TL on epithelial cells continues the selection of mature CD8αβ memory T cells. The TL-CD8αα-driven memory process is essential for the generation of memory CD8αß T cells in the intestine and leads to the accumulation of highly antigen sensitive CD8αβ memory T cells that form the first line of defense at the largest entry port for pathogens.