Institut für Technikfolgenabschätzung Elektronische Publikation
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DATUM, UNTERSCHRIFT / DATE, SIGNATURE
BANK AUSTRIA CREDITANSTALT, WIEN (IBAN AT04 1100 0006 2280 0100, BIC BKAUATWW), DEUTSCHE BANK MÜNCHEN (IBAN DE16 7007 0024 0238 8270 00, BIC DEUTDEDBMUC)
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Institut für Technikfolgenabschätzung Elektronische Publikation
Myrtill Simkó,
Dietmar Nosske,
Wolfgang G. Kreyling
doi:10.1553/ita-pa-MY-14 Eigenverlag/Self
Abstract: In: International Journal of Environmental Research and Public Health, Vol. 11 (2014), No. 4, 4026-4048; DOI: 10.3390/ijerph110404026 In order to calculate the dose for nanoparticles (NP), (i) relevant information about the dose metrics and (ii) a proper dose concept are crucial. Since the appropriate metrics for NP toxicity are yet to be elaborated, a general dose calculation model for nanomaterials is not available. Here we propose how to develop a dose assessment model for NP in analogy to the radiation protection dose calculation, introducing the so-called “deposited and the equivalent dose”. As a dose metric we propose the total deposited NP surface area (SA), which has been shown frequently to determine toxicological responses e.g. of lung tissue. The deposited NP dose is proportional to the total surface area of deposited NP per tissue mass, and takes into account primary and agglomerated NP. By using several weighting factors the equivalent dose additionally takes into account various physico-chemical properties of the NP which are influencing the biological responses. These weighting factors consider the specific surface area, the surface textures, the zeta-potential as a measure for surface charge, the particle morphology such as the shape and the length-to-diameter ratio (aspect ratio), the band gap energy levels of metal and metal oxide NP, and the particle dissolution rate. Furthermore, we discuss how these weighting factors influence the equivalent dose of the deposited NP. Keywords: nanotoxicology radiation-biology deposited-nanoparticle-dose dose-rate equivalent-dose effective-dose nanoparticle-surface-area Published Online: 2014/11/04 13:45:04 Document Date: 2014/04/14 12:00:00 Object Identifier: 0xc1aa5576 0x0031a62c Rights: . Fallweise veröffentlicht das Institut für Technikfolgen-Abschätzung zu Themen der Technikfolgen-Abschätzung in elektronischem Format. |
epub.oeaw – Institutionelles Repositorium der Österreichischen Akademie der Wissenschaften epub.oeaw – Institutional Repository of the Austrian Academy of Sciences
A-1011 Wien, Dr. Ignaz Seipel-Platz 2
Tel. +43-1-515 81/DW 3420, Fax +43-1-515 81/DW 3400 http://epub.oeaw.ac.at, e-mail: epub@oeaw.ac.at |